Toronto’s Dr. Cameron Clokie, MD Demonstrates Bone Re-Growth’s Exciting Potential

Maxillofacial and Oral Surgeon Dr. Cameron Clokie, MD has been making Canadian headlines with his cutting edge medical procedures creating bone re-growth in adult humans. The technique uses a protein that directs a certain type of stem cells, which freely circulate even in adults, to regrow broken sections of bones.

Prior to this innovation in regenerative medicine, patients had very few options. Bone grafts, implants and prosthetics do not provide nearly the same benefits as regrowing bone.

The protein was discovered in the 1950’s at the University of California at Los Angeles by the renown orthopedic surgeon and mentor under whom Dr. Clokie studied, Dr. Michael Urist, MD.

Known as bone morphogenic protein (BMP), it was learned over the years that the protein has the ability to cause stem cells in adults to be re-purposed into bone growing cells, a process akin to what occurs in newborns.

The process has been around since the late 1990’s and its use has proven beneficial in spinal re-fusing. It was uring this same period, Dr. Cameron Clokie began developing the regenerative process that would be used in facial re-construction.

By 1999, the first jaw bone repair using this technique had been realized. Unfortunately, the process requires a lot of raw bone material. Dr. Clokie’s first procedure required an amount equivalent to the leg and arm bones of 40 cadavers.

The modern BMP collection process has come a long way. A United States firm that creates the protein in Chinese hamsters using a gene insertion technique supplies Dr. Clokie’s current BMP needs. Determined to explore other avenues and increase the volume of the protein, Dr. Cameron Clokie is investigating a similar genetic technique to create BMP using goats.

In North America the procedure has already demonstrated its broad application. Peter Russel, a 60 year-old, retired investment banker, utilized the procedure to regrow tissue that was removed with a facial tumor.

The protein, in gel form, was inserted into the missing part of Russel’s jaw along with a titanium support rod. Within 5 days, blood vessels began forming around the protein gel. New connecting bone was revealed as the gel began to dissolve.

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